Extra reading - very interesting

• Ted Sturdevant Congressional Testimony - Director WA Dept of Ecology

DBP Presentation

DBP Risk Assessment PowerPoint

Background

The public is well aware of the presence of phthalates in plastic food storage containers, water bottles, baby care products, and children's toys; however, many people would be surprised to find out that phthalate exposure also occurs through our food supply. We focused our risk assessment on DBP (Dibutyl phthalate), which is commonly used as a softener in the plastic and adhesive industry. DBP is also used in the cosmetic industry to confer flexibility in nail polish and enhance the absorption of lotions. DBP is not permanently bound to the matrix of a product, so it can enter the environment and subsequently enter our food supply. Do studies indicate any adverse health effects associated with DBP exposure via the ingestion of foods containing DBP?

Studies

Evaluation of Risks to Human Reproduction: Phthalates Expert Panel Report
Rats Exposed to DBP During Gestation Exhibit Decreased Grooming Behavior
In Vitro Hormone Activities of Selected Phthalates
Effect of Oral Intake of DBP on Reproductive Parameters of Rats and Offspring
Reproductive Toxicity of Dibutyl Phthalate in a Continuous Breeding Protocol

Additional Resources

MSDS PDF

DBP Risk assessment PDF.pdf

Phthalate risks, regulation, and public health review PDF

Possible sources of infant phthalate exposure PDF

US Department of Labor OSHA Guidelines for Dibutyl-Phthalates
http://www.osha.gov/SLTC/healthguidelines/dibutylphthalate/recognition.html

Cosmetic Ingredient Raises Risk for Breast Cancer and Birth Defects
http://www.breastcancerfund.org/site/pp.asp?c=kwKXLdPaE&b=1598645

Barbie's PVC Body Gets Sticky as DBP Migrates
http://www.mindfully.org/plastic/barbies-health-hazard.htm

Chemical and Engineering News: California Bans Phthalates in Toys for Children]
[http://pubs.acs.org/cen/news/85/i43/8543news4.html]

Europa Summaries of EU Legislation: Phthalate-containing soft PVC toys and childcare articles
http://europa.eu/legislation_summaries/consumers/consumer_safety/l32033_en.htm

Consumer Product Safety Improvement Act of 2008
http://www.cpsc.gov/ABOUT/Cpsia/faq/108faq.html

Environmental Working Group's Skin Deep Cosmetic Safety Database
http://www.cosmeticsdatabase.com/ingredient.php?ingred06=701929&key=38874222

FDA: Phthalates and Cosmetic Products
http://www.fda.gov/cosmetics/productandingredientsafety/selectedcosmeticingredients/ucm128250.htm

Scientific Facts on DBP
http://www.greenfacts.org/en/dbp-dibutyl-phthalate/dbp-dibutyl-phthalate-greenfacts-level2.pdf

Healthy Child, Healthy World Chemical Encyclopedia: Phthalates
http://healthychild.org/issues/chemical-pop/phthalates/

Green Facts: Facts On Health and Environment Phthalates in School Supplies
http://copublications.greenfacts.org/en/phthalates-school-supplies/l-2/5-safe-daily-exposure.htm

US EPA Reference Dose for Chronic Oral Exposure of Dibutyl Phthalates
http://www.epa.gov/NCEA/iris/subst/0038.htm#oralrfd

Canada Gazette: Phthalates Regulations
http://www.gazette.gc.ca/rp-pr/p1/2009/2009-06-20/html/reg3-eng.html

Letters and Editorials

Lani's Letter
Lani's Editorial

 Chlorpyrifos Risk Assessment

Background: Chlorpyrifos is a widely used organophosphate pesticide - 5.5 million pounds per year are used on corn alone in the United States. Chlorpyrifos is an acetylcholinesterase inhibitor, and short-term exposure can result in dizziness, nausea, vomiting, and paralysis. This risk assessment focuses on long-term exposure to chlorpyrifos in infants and children, which can have significantly deleterious cognitive, psychomotor, and behavioral consequences. Exposure risks are particularly pronounced in agricultural communities, where farm workers and their families are consistently privy to extremely elevated levels of chlorpyrifos in their environment and in their homes. Chlorpyrifos is currently undergoing re-registration review by the EPA to determine whether it is safe for continued use.

Acetylcholinesterase inhibition:

 

Presentation

Chlorpyrifos Powerpoint

 Resources

EPA - Chlorpyrifos Fact Sheet:

http://www.epa.gov/pesticides/reregistration/REDs/factsheets/chlorpyrifos_fs.htm

EPA - Chlorpyrifos Risk Information:

http://www.epa.gov/iris/subst/0026.htm

EPA - Chlorpyrifos Interim Risk Management Decision:

http://www.epa.gov/oppsrrd1/reregistration/chlorpyrifos/

ATSDR - Chlorpyrifos ToxFAQs: 

http://www.atsdr.cdc.gov/tfacts84.html

Pesticide Action Network - Chlorpyrifos:

http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33392

National Agricultural Statistics Service - Agricultural Chemical Use Database:

http://www.pestmanagement.info/nass/app_usage.cfm

National Resources Defense Council - Our Children At Risk: 

http://www.nrdc.org/health/kids/ocar/chap5b.asp

Dow Chemical - Chlorpyrifos Protects:

http://www.chlorpyrifos.com/

NPR - "Pesticide drift eluding efforts to combat it", 2/28/10:

http://www.npr.org/templates/story/story.php?storyId=123817702

Eskenazi, et al. Exposures of children to organophosphate pesticides and their potential adverse health effects.

Fenske, et al. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State.

Fenske, et al. Biologically based pesticide dose estimates for children in an agricultural community.

Fenske, et al. Potential exposure and health risks of infants following indoor residential pesticide applications.

Gore. Environmental Toxicant Effects on Neuroendocrine Function.

Griffin, et al. Oral and dermal absorption of chlorpyrifos: a human volunteer study.

Gurunathan, et al. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children.

Rauh, et al. Impact of Prenatal Chlorpyrifos Exposure on Neurodevelopment in the First 3 Years of Life Among Inner-City Children.

Simcox, et al. Pesticides in household dust and soil: exposure pathways for children of agricultural families.

Slotkin and Seidler. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent.

Letter and Op-ed

Children and Chlorpyrifos Op-Ed

Chorlpyrifos Letter 

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